Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov

نویسندگان

  • Xian-Wen Yang
  • Gai-Yun Zhang
  • Jian-Xi Ying
  • Bing Yang
  • Xue-Feng Zhou
  • Andre Steinmetz
  • Yong-Hong Liu
  • Ning Wang
چکیده

One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2-6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).

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عنوان ژورنال:

دوره 11  شماره 

صفحات  -

تاریخ انتشار 2012